Description
Genticyn® Eye Drops are manufactured by Allergan. Genticyn® contains an active ingredient called Gentamicin – an Aminoglycoside antibiotic, derived from an actinomycete.
Indications:
- bacterial eye infections (conjunctivitis, keratitis, keratoconjunctivitis, corneal ulcers, blepharitis, blepharoconjunctivitis, acute meibomianitis, and dacryocystitis) caused by Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus pneumoniae, Enterobacter aerogenes, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Neisseria gonorrhoeae, Pseudomonas aeruginosa, and Serratia marcescens.
MOA (mechanism of action):
Gentamicin binds to the bacterial 30S ribosomal subunit. Ribosomes, which produce protein, are composed of two subunits in bacteria, a 30S and a larger 50S. By binding to the ribosome, Gentamicin inhibits the translocation of tRNA during translation and leaves the bacterium unable to synthesize proteins necessary for growth. Gentamicin does not interfere with protein synthesis in human cells.
Dosage
For mild to moderate infections: instill 1 or 2 drops into the treated eye(s) every 4 hours.
For severe infections: instill 2 drops into the treated eye(s) every hour until improvement occurs.
Precautions:
Eyebrex® solution is not for injection.
Gentamicin solution is associated with allergic reactions, even following a single dose. Discontinue using drops immediately and contact your physician at the first sign of a rash or allergic reaction.
Prolonged use of Genticyn® Eye Drops may result in overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, discontinue using these drops and institute alternative therapy.
Avoid contaminating the applicator tip with eye, fingers or another source.
Eyebrex® eye drops may cause your vision to blur temporarily after you have applied them into your eye. Do not drive or operate machinery until this has worn off.
Patients should not wear contact lenses while using Gentamicin solution for eye infection.
Wash your hands before using the eye drops.
Missing a dose
If you miss a dose you should instill it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not instill a double dose to make up for a missed one.
Overdose
If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately. A topical overdose of Genticyn® Eye Drops may be flushed from the eye(s) with lukewarm tap water.
Storage
Store at cool room temperature, away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use. Use within one month after opening a container. Keep out of the reach of children.
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