Description
Clonil® SR is manufactured by Intas. Its main component is Clomipramine, a tricyclic antidepressant (TCA). Clonil® SR is designed in a form of sustained-release tablets, which release the drug at a predetermined rate in order to provide a steady drug concentration for a specific period of time causing minimum side effects.
Indications:
- depression or MDD (major depressive disorder) – feeling sad, inability to sleep properly or to enjoy life as one used to);
- OCD (obsessive compulsive disorders), or obsessive behaviors (compulsive or irrational preoccupation);
- phobias (strong fear of something, which is actually irrational);
- muscular weakness (cataplexy) associated with repeat attacks of extreme sleepiness (narcolepsy);
- off-label treatment of premature ejaculation (PE), (or too early ejaculation within 1 minute after penetration). Clomipramine is able to prolong the coitus time.
MOA (mechanism of action):
Clomipramine enhances the actions of norepinephrine and serotonin (chemical neurotransmitters in the brain used by nerves to communicate with each other) by blocking their reuptake and prolonging their activity. Clomipramine also has a wide pharmacological spectrum of action, which includes alpha1- adrenolytic, anticholinergic, antihistaminic, and antiserotonergic (5-HT-receptor blocking) properties.
Dosage
Clonil® SR is used only in adults over 17 years of age.
Swallow Clonil® SR tablet whole with a drink of water.
For depression: initially 10 mg, which can be increased to find a dose that works for you. This is normally 30-150 mg daily, maximum of 250 mg daily for severe conditions.
For obsessions and phobias: initially 25 mg, which can be increased to 100-150 mg daily.
For cataplexy: initially 10 mg, which can be increased to a maximum of 75 mg daily.
Elderly patients often need a lower dose. The maximum dose for elderly patients is 75 mg daily.
Precautions:
It can take 4 to 6 weeks for Clonil® SR to start working. You should continue the treatment for at least 6 months after you feel better to stop depression from coming back.
Clonil® SR can make feel sleepy so a doctor may advise patient taking a small dose when starting treatment. Then the dose can be increased gradually as the body gets used to it.
When stopping treatment with Clonil® SR, it is best to decrease the dose gradually over a period of several weeks or months to minimize the withdrawal reactions.
Missing a dose
If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose of Clonil® SR to compensate the missed dose.
Overdose
If you take an overdose of Clonil® SR, you should seek emergency medical attention or contact your healthcare provider immediately.
Storage
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.
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